Recent and ongoing selection in the human genome
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Recent and ongoing selection in the human genome. / Nielsen, Rasmus; Hellmann, Ines; Hubisz, Melissa; Bustamante, Carlos; Clark, Andrew G.
In: Nature Reviews. Genetics, Vol. 8, No. 11, 2007, p. 857-68.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Recent and ongoing selection in the human genome
AU - Nielsen, Rasmus
AU - Hellmann, Ines
AU - Hubisz, Melissa
AU - Bustamante, Carlos
AU - Clark, Andrew G
N1 - Keywords: Evolution, Molecular; Genetics, Population; Genome, Human; Humans; Selection (Genetics)
PY - 2007
Y1 - 2007
N2 - The recent availability of genome-scale genotyping data has led to the identification of regions of the human genome that seem to have been targeted by selection. These findings have increased our understanding of the evolutionary forces that affect the human genome, have augmented our knowledge of gene function and promise to increase our understanding of the genetic basis of disease. However, inferences of selection are challenged by several confounding factors, especially the complex demographic history of human populations, and concordance between studies is variable. Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings.
AB - The recent availability of genome-scale genotyping data has led to the identification of regions of the human genome that seem to have been targeted by selection. These findings have increased our understanding of the evolutionary forces that affect the human genome, have augmented our knowledge of gene function and promise to increase our understanding of the genetic basis of disease. However, inferences of selection are challenged by several confounding factors, especially the complex demographic history of human populations, and concordance between studies is variable. Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings.
U2 - 10.1038/nrg2187
DO - 10.1038/nrg2187
M3 - Journal article
C2 - 17943193
VL - 8
SP - 857
EP - 868
JO - Nature Reviews. Genetics
JF - Nature Reviews. Genetics
SN - 1471-0056
IS - 11
ER -
ID: 11529433